NAD+(NJ500)

NAD+(NJ500)

Nicotinamide Adenine Dinucleotide (NAD+) is a fundamental coenzyme found in every living cell that serves as a critical electron carrier in mitochondrial energy production and as a vital substrate for sirtuins and PARPs, enzymes central to regulating aging, DNA repair, and inflammation.

With a molecular weight of 663.43 g/mol, declining NAD+ levels are a hallmark of aging, and supplementation in experimental models reverses age-related mitochondrial dysfunction, improves metabolic homeostasis, and extends healthspan through SIRT1 activation.

It demonstrates neuroprotective actions in Parkinson’s disease models by protecting dopamine-producing cells, maintains DNA integrity by serving as substrate for PARP enzymes in repair, and modulates inflammatory pathways via NAMPT regulation.