TB-500 (Thymosin Beta-4)

TB-500 is the synthetic version of Thymosin Beta-4, a 43-amino-acid peptide (MW 4963 g/mol) that regulates cytoskeleton dynamics by binding to and sequestering globular actin, critical for cell motility and structural change.

TB-500 (Thymosin Beta-4) (5mg)

It promotes angiogenesis by upregulating microRNA-146a to suppress pro-inflammatory pathways, and in injury models accelerates wound healing by increasing IL-1β and IL-6 while subsequently reducing pro-inflammatory chemoattractants.

Its anti-apoptotic properties inhibit programmed cell death in corneal epithelial and cardiac cells by blocking caspases and activating survival kinases like Akt, and in cardiac research it promotes heart cell survival and repair by activating integrin-linked kinase.

TB-500 (Thymosin Beta-4) (10mg)

TB-500 is the synthetic version of Thymosin Beta-4, a 43-amino-acid peptide (MW 4963 g/mol) that is the principal actin-sequestering molecule in eukaryotic cells, regulating cytoskeleton dynamics critical for cell movement and migration via its conserved actin-binding domain LKKTETQ.

TB-500 (Thymosin Beta-4) (10mg)

It upregulates microRNA-146a to suppress pro-inflammatory cytokines, promotes angiogenesis, and accelerates recovery in corneal, dermal, and cardiac tissue models. In the heart, it reduces cardiomyocyte apoptosis, increases the survival kinase Akt, and promotes cardiac repair by activating integrin-linked kinase, while its low molecular weight allows it to travel long distances through tissues for systemic effects from local introduction.