Semax

Semax is a synthetic heptapeptide analog of ACTH(4-10) with a C-terminal Pro-Gly-Pro extension and N-terminal acetylation, designed to enhance lipophilicity and stability for crossing the blood-brain barrier.

Semax

With a molecular weight of 854.99 g/mol, it functions as a nootropic and neuroprotective agent by promoting expression of neurotrophic factors like BDNF and NGF in the hippocampus and frontal cortex, enhancing neuroplasticity and memory consolidation.

In stroke models, it reduces infarct size and improves functional recovery by modulating immune and vascular systems, and it influences neurotransmitter systems by increasing serotonin and dopamine metabolite levels while potentially inhibiting enkephalin-degrading enzymes for mood enhancement.